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Dihydrolipoyl transacetylase (or dihydrolipoamide acetyltransferase) is an enzyme component of the multienzyme pyruvate dehydrogenase complex. The pyruvate dehydrogenase complex is responsible for the pyruvate decarboxylation step that links glycolysis to the citric acid cycle. This involves the transformation of pyruvate from glycolysis into acetyl-CoA which is then used in the citric acid cycle to carry out cellular respiration. There are three different enzyme components in the pyruvate dehydrogenase complex. Pyruvate dehydrogenase (EC 1.2.4.1) is responsible for the oxidation of pyruvate, dihydrolipoyl transacetylase (this enzyme; EC 2.3.1.12) transfers the acetyl group to coenzyme A (CoA), and dihydrolipoyl dehydrogenase (EC 1.8.1.4) regenerates the lipoamide. Because dihydrolipoyl transacetylase is the second of the three enzyme components participating in the reaction mechanism for conversion of pyruvate into acetyl CoA, it is sometimes referred to as E2. In humans, dihydrolipoyl transacetylase enzymatic activity resides in the pyruvate dehydrogenase complex component E2 (PDCE2) that is encoded by the ''DLAT'' (dihydrolipoamide S-acetyltransferase) gene. == Nomenclature == The systematic name of this enzyme class is acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase. Other names in common use include: * acetyl-CoA:dihydrolipoamide S-acetyltransferase, * acetyl-CoA:enzyme 6-N-(dihydrolipoyl)lysine S-acetyltransferase. * dihydrolipoamide S-acetyltransferase, * dihydrolipoate acetyltransferase, * dihydrolipoic transacetylase, * dihydrolipoyl acetyltransferase, * enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase, * lipoate acetyltransferase, * lipoate transacetylase, * lipoic acetyltransferase, * lipoic acid acetyltransferase, * lipoic transacetylase, * lipoylacetyltransferase, * thioltransacetylase A, and * transacetylase X. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「dihydrolipoyl transacetylase」の詳細全文を読む スポンサード リンク
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